The Women’s research team attracting international attention

Brett Manley and Peter Davis
Dr Brett Manley with Professor Peter Davis, Director of the Women's Newborn Research Centre
14 October 2013 | Research and clinical trials

Study at the Women's confirms new breathing support for preterm babies is safe and effective.

A team at the Newborn Research Centre at the Royal Women’s Hospital (the 
Women’s) has found that a cheaper, more comfortable method of supporting the 
breathing of very preterm babies is safe and effective. 
The results of the team’s two-year investigation, the largest of its kind in the world, 
were published on Thursday in the New England Journal of Medicine. 
Lead author Dr Brett Manley, a Neonatologist at the Women’s, said the project had 
attracted international interest. The use of high-flow nasal cannulae (simple, small 
prongs in the baby’s nose) was becoming a more popular alternative to the traditional 
continuous positive airway pressure (CPAP) method, which requires larger prongs 
and cumbersome tubing that is wrapped across the baby’s head. 
Dr Manley said until now there was little evidence to confirm the efficacy of high-flow nasal cannulae. 
The research showed that when used to support very preterm (less than 32 weeks’ 
gestation) babies’ breathing after coming off a mechanical ventilator (breathing 
machine), high-flow nasal cannulae were as safe as the CPAP method and also 
caused less irritation to the skin around the nose and allowed the babies to be held 
more easily by their parents. 
The trial involved 303 babies at the Women’s in Melbourne, the Women’s and 
Children’s Hospital in Adelaide and the Royal Brisbane and Women’s Hospital. 
Professor Peter Davis, the director of the Women’s Newborn Research Centre said 
high-flow nasal cannulae were easier for the staff to apply and allowed parents to 
hold their baby more easily. “Importantly, the babies seem to like it,” Prof. Davis said. 
CPAP has been the traditional system of providing breathing support to very preterm 
babies after coming off a mechanical ventilator. CPAP is quite restrictive as the 
device must be strapped around the baby’s head to keep it firmly in place. 
Media Release  
 “The CPAP device can also be intimidating to some parents and may interfere with 
bonding between babies and parents,” Dr Manley said. 
“An advantage of high-flow nasal cannulae is that they are easier to use and do not 
require such intensive nursing care to administer”. 
“We found high-flow nasal cannulae to be an effective alternative to CPAP.” 
The research by the team – that also included Dr Louise Owen and Professor Lex 
Doyle from the Women’s Newborn Research Centre - was funded by the National 
Health and Medical Research Council. 

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