New test predicts potentially deadly pre-eclampsia

Hannah Torres developed pre-eclampsia when pregnant with her first baby, Mateo
Hannah Torres developed pre-eclampsia when pregnant with her first baby, Mateo
3 May 2018 | Fundraising | Pregnancy and newborns | Research and clinical trials

The Royal Women’s Hospital has become the first Australian hospital to introduce a new blood test to help predict who will and will not develop the potentially deadly pregnancy condition pre-eclampsia.

It comes after the hospital’s Director of Pregnancy Research, Professor Shaun Brennecke, led the Australian arm of an international study trialling the new test, finding it could predict the likelihood or not of women developing pre-eclampsia in the following four weeks.

Women who have experienced pre-eclampsia in a previous pregnancy or who have symptoms or signs of the condition are being given the test, called pre-eclampsia ratio test (PERT).

Pre-eclampsia is the most common serious medical disorder in pregnancy across the world and can be life-threatening for both mother and babies. About one in 20 pregnant women experience pre-eclampsia, which leads to dangerously high blood pressure in a pregnant woman and can involve her kidneys, liver, brain and other organ systems.

“This new test is a long awaited and very important step forward,” Professor Brennecke said. “Not only does this new test help diagnose pre-eclampsia, but even more importantly, it also helps predict who will and who will not develop pre-eclampsia, including those without clear symptoms or signs, over the following month.

“Currently, the only way to cure pre-eclampsia is to end the pregnancy by delivering the baby, even if the pregnancy is still many weeks from full term, in which case such prematurity can have significant implications for the long term health of the baby.”

“This test allows clinicians to understand the severity of the pre-eclampsia and to decide the best time to deliver the baby.”

Professor Shaun Brennecke
Professor Shaun Brennecke

The announcement comes during the Women’s Miracle Mums Appeal with funds raised going towards research into preventing problems in pregnancy and helping preterm babies.

Prof Brennecke said using PERT at the Women’s has shown two thirds of women with symptoms or signs suggestive of possible pre-eclampsia will test negative for the condition, which brings significant relief for all concerned.

“In the past, we admitted women to hospital for monitoring if we suspected they had pre-eclampsia. Now we can reassure the women who test negative that they are very unlikely to develop the condition in the next four weeks.”

“This significantly reduces anxiety, especially for women who have experienced pre-eclampsia in the past and therefore are at much higher risk of developing it again. It also allows us to focus our health resources on those at high risk for pre-eclampsia.”

Women with risk factors for pre-eclampsia are prescribed low dose aspirin from 12 weeks of their pregnancy, which significantly reduces the risk of developing pre-eclampsia later in the pregnancy, but it is not an effective treatment once pre-eclampsia is present. 

The new test establishes a high and low result based on the measurement of two proteins, which are released from the placenta in abnormal amounts in pregnant women destined to develop pre-eclampsia. Those with a very low risk of developing pre-eclampsia will show a low level of these proteins, and those with a high level will be much more likely to develop pre-eclampsia. 

Laboratory Services staff at the Royal Children's Hospital worked with Prof Brennecke to support the introduction of the test.

Hannah Torres developed pre-eclampsia in the late stages of her pregnancy with son Mateo.

“I had felt sick for a few days but I just thought, ‘well I’m pregnant, this is what can happen’,” Mrs Torres said.  

After delivering Mateo, Mrs Torres became severely unwell as a result of the pre-eclampsia and spent a week in critical care. “I didn’t realise until afterwards just how serious it was and what complications it can cause,” she said.

“Knowing that for future pregnancies I can have a test to tell me if I’m at risk of developing it again, I think that’s wonderful.”

Please give generously so Professor Brennecke and his team can continue their vital research looking at treatments for pre-eclampsia by donating now. 

About pre-eclampsia

The cause of pre-eclampsia is unknown. Women at higher risk include those:       

  • having their first baby
  • with a history of pre-eclampsia in a previous pregnancy
  • with a family history of pre-eclampsia or high blood pressure
  • who are under age 20 and over age 40
  • who are having twins or multiples
  • with high blood pressure before pregnancy
  • with kidney disease before pregnancy
  • with diabetes
  • who have a body mass index (BMI) over 30

If left untreated, pre-eclampsia can lead in the mother to liver or kidney failure, seizures, stroke and death. For the baby, pre-eclampsia can affect the placenta and decrease the fetal supply of oxygen and food, leading to slower growth in the womb, a low birth weight, premature birth and in some cases, death.

Accessing the test

The test is currently available to patients at the Royal Women's Hospital and the blood samples are analysed by pathology services at the Royal Children's Hospital.

Patients interested in accessing the test should discuss it with their obstetrician.

Clinicians wishing to refer samples for testing can contact the Biochemistry Department, Laboratory Services at the Royal Children's Hospital

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